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KMID : 1189420080210030020
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2008 Volume.21 No. 3 p.20 ~ p.35
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Effects of Curcuma longa Rhizoma on Asthma induced intra-nasal instillation of Ovalbumin in Mice
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Lee Jun-Hun
Kim Jong-Han
Park Su-Yeon
Choi Jung-Hwa
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Abstract
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Objective : This study was designed to investigate the effects of Curcuma longa Rhizoma(CLR) on asthma.
Methods : Detecting splenocyte proliferation rates, cytokines and antigen specific antibody isotypes in bronchoalveolar lavage fluid (BALF). In addition, the present author I also investigated changes in spleen and histopathological changes of lung tissues.
Results : Oral administration of CLR lowered spleen weight and splenocyte proliferation rates. In addition, levels of IL-4, IL-17A and Granulocyte/Macrophage Colony-Stimulating Factor(GM-CSF), Th2 driven cytokines, were lowered respectively and IFN-g, and Th1 driven cytokine, were elevated by CLR. Levels of Ovalbumin(OVA) specific IgE and IgG1 in BALF were also lowered by oral administration of CLR too.
Conclusion : CLR is useful to treat patients with asthma and the mechanisms are related to the in suppression of Th2 skewing reactions.
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KEYWORD
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Curcuma longa Rhizoma, Asthma
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